elegans orthologs than would be expected by chance, but they do harbor motifs that are important for proper expression of the C. We show that functionally conserved cis-regulatory elements have no more extended sequence similarity to their C. Despite the great phylogenetic distances sampled and the extensive sequence divergence of nematode genomes, all but one of the regulatory elements we tested are able to drive at least a subset of the expected gene expression patterns. briggsae, and three parasitic species Meloidogyne hapla, Brugia malayi, and Trichinella spiralis, represent four of the five major clades in the phylum Nematoda. These species, Caenorhabditis elegans, its congeneric C.

To test conservation of gene regulation within the phylum Nematoda, we compared the functions of putative cis-regulatory sequences of four sets of orthologs (unc-47, unc-25, mec-3 and elt-2) from distantly-related nematode species. Gene regulatory information guides development and shapes the course of evolution.

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